Essential oil of Myrciaria tenella (DC.) O. Berg: effects of distillation time on its chemical composition and evaluation of its anti-inflammatory and antinociceptive effects

The objective of the present study was to characterize essential oil Myrciaria tenella (MTEO) leaves, determine effects distillation time (1 5 h), and evaluate its action on acute pain inflammation both in vivo vitro. MTEO obtained by hydrodistillation for 4 h 36 compounds were detected, mainly consisting hydrocarbon terpenes such as β-pinene (21.46%), α-pinene (19.43%), E-caryophyllene (10.89%) aromadendrene (9.17%). A high yield α-pinene/β-pinene-rich after only 2 extraction. For biological assays, administered male Swiss mice, showing an against hypernociception (acetic acid-induced abdominal writhing, formalin Von Frey models) inhibiting carrageenan-induced paw edema. Production IL-6, TNF-α, IL-1β, PGE2 reduced production IL-10 increased, with no change motor performance. also cell NO cytokines, addition COX activity.